EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia

Volume: 1863, Issue: 9, Pages: 1029 - 1040
Published: Sep 1, 2018
Abstract
Prostaglandin E receptor subtype 4 (EP4) knockout mice develops spontaneous hypercholesterolemia but the detailed mechanisms by which EP4 affects cholesterol homeostasis remains unexplored. We sought to determine the cause of hypercholesterolemia in EP4 knockout mice, focusing on the role of EP4 in regulating the synthesis and elimination of cholesterol. Deficiency of EP4 significantly decreased total bile acid levels in the liver by 26.2% and...
Paper Details
Title
EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia
Published Date
Sep 1, 2018
Volume
1863
Issue
9
Pages
1029 - 1040
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.