Factor X heterozygous mutation in a patient with potential risk of bleeding

Rationale: Factor X (FX) deficiency is a rare autosomal recessive bleeding disorder. The majority of patients carry a missense mutation in F10, and patients with bleeding disorders are either homozygous or compound heterozygous for F10. Nonsense mutations are exceptionally rare, and a heterozygous nonsense mutation is not considered to cause bleeding disorders. Patient concerns: A 35-year-old Japanese female with an incidental hemorrhage after...