Insulin Potentiates Neuronal Responses to Chemical Stimulation in Thin Muscle Afferents and Dorsal Root Ganglia

The cardiovascular response to physical activity is abnormally exaggerated in patients with type 2 diabetes mellitus (T2D). Recent studies in patients with T2D have suggested that this exaggerated responsiveness is mediated, in part, by the skeletal muscle metaboreflex. However, the mechanisms causing augmentations in muscle metaboreflex function in this disease remain to be elucidated. Chronic hyperinsulinemia associated with peripheral insulin...