Breast cancer cell-free DNA (cfDNA) profiles reflect underlying tumor biology: The Circulating Cell-Free Genome Atlas (CCGA) study.

536 Background: New breast cancer screening approaches are needed to detect clinically aggressive subtypes that may not be detected by mammography or are detected late in unscreened populations. CCGA (NCT02889978) is a prospective multi-center observational study for the development of a noninvasive assay for cancer detection. A preplanned substudy of a Women-Only Cohort is reported. Methods: Blood was prospectively collected (N = 1627) from 878...