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Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

Published on Dec 1, 2018
· DOI :10.1038/s42003-018-0059-x
David J. Duffy8
Estimated H-index: 8
(Bangor University),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 10 AuthorsMark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
Cite
Abstract
Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are required to help maintain healthy populations until the chronic underlying causes of these issues can be addressed. Fibropapillomatosis in sea turtles is one such wildlife disease. Here, we applied precision-medicine-based approaches to profile fibropapillomatosis tumors to better understand their biology, identify novel therapeutics, and gain insights into viral and environmental triggers for fibropapillomatosis. We show that fibropapillomatosis tumors share genetic vulnerabilities with human cancer types, revealing that they are amenable to treatment with human anti-cancer therapeutics.
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  • References (105)
  • Citations (3)
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References105
Newest
Published on Apr 1, 2018in American Journal of Clinical Dermatology 3.84
Alice Y. Zhou1
Estimated H-index: 1
(VUMC: Vanderbilt University Medical Center),
Douglas B. Johnson35
Estimated H-index: 35
(VUMC: Vanderbilt University Medical Center)
Melanoma is the most aggressive of the skin cancers, with historically high rates of morbidity and mortality due to its resistance to traditional cytotoxic therapies. Recently, however, breakthroughs in new therapies have dramatically changed clinical outcomes of this disease. These advances emerged from an improved understanding of tumor oncogenesis and the interacting tumor microenvironment. Small molecules that target the oncogenic mitogen-activated protein kinase (MAPK) pathway, specifically...
Published on Feb 20, 2018in PeerJ 2.35
Cheryl L. Morrison14
Estimated H-index: 14
(USGS: United States Geological Survey),
Luke R. Iwanowicz20
Estimated H-index: 20
(USGS: United States Geological Survey)
+ 7 AuthorsRobert S. Cornman10
Estimated H-index: 10
(USGS: United States Geological Survey)
Published on Dec 1, 2017
Geoffrey M. Wahl72
Estimated H-index: 72
(Salk Institute for Biological Studies),
Benjamin T. Spike18
Estimated H-index: 18
(UofU: University of Utah)
Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistance. Here, we consider not only genetic and epigenetic mechanisms, but also inflammation and cell state reprogramming in creating tumor heterogeneity. We discuss similarities between normal mammary epithelial developmental states and various breast cancer molec...
Published on Dec 1, 2017in Science of The Total Environment 5.59
Justin R. Perrault9
Estimated H-index: 9
(Mote Marine Laboratory),
Nicole I. Stacy6
Estimated H-index: 6
(UF: University of Florida)
+ 6 AuthorsCatherine J. Walsh13
Estimated H-index: 13
(Mote Marine Laboratory)
Abstract Natural biotoxins and anthropogenic toxicants pose a significant risk to sea turtle health. Documented effects of contaminants include potential disease progression and adverse impacts on development, immune function, and survival in these imperiled species. The shallow seagrass habitats of Florida's northwest coast (Big Bend) serve as an important developmental habitat for Kemp's ridley ( Lepidochelys kempii ) and green ( Chelonia mydas ) sea turtles; however, few studies have been con...
Published on Dec 1, 2017in Genome Medicine 10.89
David J. Duffy8
Estimated H-index: 8
,
Aleksandar Krstic8
Estimated H-index: 8
(UCD: University College Dublin)
+ 5 AuthorsWalter Kolch76
Estimated H-index: 76
(UCD: University College Dublin)
Background Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer re...
Published on Dec 1, 2017in American Journal of Clinical Dermatology 3.84
Antonio Maria Grimaldi16
Estimated H-index: 16
,
Ester Simeone25
Estimated H-index: 25
+ 3 AuthorsPaolo Antonio Ascierto58
Estimated H-index: 58
The mitogen-activated protein kinase (MAPK) cascade is an intracellular signaling pathway involved in the regulation of cellular proliferation and the survival of tumor cells. Several different mutations, involving BRAF or NRAS, exert an oncogenic effect by activating the MAPK pathway, resulting in an increase in cellular proliferation. These mutations have become targets for new therapeutic strategies in melanoma and other cancers. Selective MEK inhibitors have the ability to inhibit growth and...
Published on Oct 18, 2017in PLOS ONE 2.78
Caspar A. Hallmann7
Estimated H-index: 7
(Radboud University Nijmegen),
Martin Sorg1
Estimated H-index: 1
+ 9 AuthorsThomas Hörren1
Estimated H-index: 1
Global declines in insects have sparked wide interest among scientists, politicians, and the general public. Loss of insect diversity and abundance is expected to provoke cascading effects on food webs and to jeopardize ecosystem services. Our understanding of the extent and underlying causes of this decline is based on the abundance of single species or taxonomic groups only, rather than changes in insect biomass which is more relevant for ecological functioning. Here, we used a standardized pr...
Published on Oct 1, 2017in Transboundary and Emerging Diseases 3.55
R.M. Gil da Costa8
Estimated H-index: 8
(University of Porto),
M. C. Peleteiro1
Estimated H-index: 1
(University of Lisbon)
+ 1 AuthorsDaniel DiMaio41
Estimated H-index: 41
Summary Over recent years, a growing number of papillomaviruses have been identified, which cause a wide range of lesions in domestic and wild animals. Papillomavirus-induced lesions may have a great impact on animal health, and some diseases observed in farm animals are associated with significant economic losses. This concise review brings together recent advancements on animal papillomavirus research, providing the scientific community and veterinary practitioners with an update on this rapid...
Published on Sep 1, 2017in Journal of Virology 4.32
Thierry M. Work32
Estimated H-index: 32
(USGS: United States Geological Survey),
Julie Dagenais5
Estimated H-index: 5
(USGS: United States Geological Survey)
+ 2 AuthorsMathias Ackermann37
Estimated H-index: 37
ABSTRACT Fibropapillomatosis (FP) is a tumor disease of marine turtles associated with chelonid herpesvirus 5 (ChHV5), which has historically been refractory to growth in tissue culture. Here we show, for the first time, de novo formation of ChHV5-positive intranuclear inclusions in cultured green turtle cells, which is indicative of active lytic replication of the virus. The minimal requirements to achieve lytic replication in cultured cells included (i) either in vitro cultures of ChHV5-positi...
Published on Sep 1, 2017in Ecohealth 2.23
Andrea Chaves3
Estimated H-index: 3
(UCR: University of Costa Rica),
A. Alonso Aguirre13
Estimated H-index: 13
(GMU: George Mason University)
+ 10 AuthorsLuis Fonseca1
Estimated H-index: 1
Marine turtle fibropapillomatosis (FP) is a devastating neoplastic disease characterized by single or multiple cutaneous and visceral fibrovascular tumors. Chelonid alphaherpesvirus 5 (ChHV5) has been identified as the most likely etiologic agent. From 2010 to 2013, the presence of ChHV5 DNA was determined in apparently normal skin, tumors and swab samples (ocular, nasal and cloacal) collected from 114 olive ridley (Lepidochelys olivacea) and 101 green (Chelonia mydas) turtles, with and without ...
Cited By3
Newest
Published on Feb 7, 2019
David J. Duffy (Whitney Laboratory for Marine Bioscience), Mark Q. Martindale58
Estimated H-index: 58
(Whitney Laboratory for Marine Bioscience)
Our recent Communications Biology research article revealed the genomic drivers and therapeutic vulnerabilities of sea turtle fibropapillomatosis tumors. Fibropapillomatosis is a debilitating tumorous disease afflicting populations of green sea turtles globally. While a virus is involved in the development of this disease, it is increasingly understood that the key trigger is linked to anthropogenic disturbances of the environment. The specific environmental co-trigger(s) has yet to be functiona...
Published on Jan 1, 2019in Journal of Exotic Pet Medicine 0.24
Fábio Parra Sellera7
Estimated H-index: 7
(USP: University of São Paulo),
Gustavo Henrique Pereira Dutra5
Estimated H-index: 5
+ 5 AuthorsFabio Celidonio Pogliani6
Estimated H-index: 6
(USP: University of São Paulo)
Abstract A pilot study was performed to investigate fibropapillomatosis (FP) recurrence rates after 940 nm-diode laser surgeries. Fifteen animals had a total of 274 tumors removed by diode laser. Cutaneous FP recurrence rates were evaluated during a period of 1-year. According to tumor sizes classification, 166 tumors (60.6%) were 4-10 cm and 10 tumors (3.6%) >10 cm. Seven animals (46.6%) were lightly afflicted, 4 (26.7%) moderately, and 4 (26.7%) heavily afflicted. Thirteen animals (86.7%) did ...