Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC Base Pair with the TFO Containing One <i>N</i><sup>2</sup>-Phenyl-2′-deoxyguanosine

Volume: 66, Issue: 6, Pages: 624 - 631
Published: Jun 1, 2018
Abstract
The antiparallel triplex DNA is formed by the interaction between purine-rich triplex forming oligonucleotides (TFOs) and the homo-purine region within a duplex DNA. The formation of such a structure with the genome DNA promises to control the gene expression in a living cell. In this study, in an attempt to enhance the stability of the triplex DNAs, we have designed the N2-arylated deoxyguanosine derivatives. Among these analogues, we found...
Paper Details
Title
Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC Base Pair with the TFO Containing One <i>N</i><sup>2</sup>-Phenyl-2′-deoxyguanosine
Published Date
Jun 1, 2018
Volume
66
Issue
6
Pages
624 - 631
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