Match!

Plasma Galectin-3 and Sonographic Measures of Carotid Atherosclerosis in the Atherosclerosis Risk in Communities Study

Published on Jan 1, 2019in Angiology2.376
路 DOI :10.1177/0003319718780772
Abayomi O. Oyenuga1
Estimated H-index: 1
(UMN: University of Minnesota),
Aaron R. Folsom159
Estimated H-index: 159
(UMN: University of Minnesota)
+ 2 AuthorsChristie M. Ballantyne35
Estimated H-index: 35
(Houston Methodist Hospital)
Abstract
  • References (53)
  • Citations (2)
馃摉 Papers frequently viewed together
2011
8 Authors (Kelly A. Volcik, ..., Yijuan Hu)
25 Citations
4 Citations
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References53
Newest
#1Oluwaseun E. Fashanu (UMN: University of Minnesota)H-Index: 3
#2Faye L. Norby (UMN: University of Minnesota)H-Index: 12
Last. Aaron R. Folsom (UMN: University of Minnesota)H-Index: 159
view all 9 authors...
Background Galectin-3, a 尾-galactoside binding lectin involved in important regulatory roles in adhesion, inflammation, immunity, and fibrosis, may be relevant to atrial fibrillation (AF) etiology. Methods We included 8,436 participants free of AF at baseline (1996-1998) and with measures of plasma galectin-3 from the Atherosclerosis Risk in Communities study. We ascertained incident AF through 2013 from study visit electrocardiograms, hospitalizations, and death certificates. Multivariable Cox ...
7 CitationsSource
BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1尾, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The ...
1,434 CitationsSource
Galectins are a group of evolutionarily conserved proteins with the ability to bind 尾-galactosides through characteristic carbohydrate-recognition domains (CRD). Galectin-3 is structurally unique among all galectins as it contains a C-terminal CRD linked to an N-terminal protein-binding domain, being the only chimeric galectin. Galectin-3 participates in many functions, both intra- and extracellularly. Among them, a prominent role for Galectin-3 in inflammation has been recognized. Galectin-3 ha...
20 CitationsSource
#1Xin-Wei He (WMU: Wenzhou Medical College)H-Index: 4
#2Wei-Ling Li (WMU: Wenzhou Medical College)H-Index: 4
Last. Xiao-Ping Jin (WMU: Wenzhou Medical College)H-Index: 6
view all 7 authors...
The aim of this study was to assess the expression patterns of serum galectin-1 (Gal-1), galectin-3 (Gal-3), galectin-9 (Gal-9), and galectin-3 binding protein (Gal-3BP) and their associations with stroke outcome in large artery atherosclerotic (LAA) stroke. The serum levels of Gal-1, Gal-3, Gal-9, and Gal-3BP were measured by ELISA in 130 patients with LAA stroke and 130 age- and sex-matched controls. Serum samples were collected from the patients on day 1, day 6, and in the 4th week after isch...
14 CitationsSource
#1Wei-Sheng Chen (Tufts University)H-Index: 10
#2Zhiyi Cao (Tufts University)H-Index: 18
Last. Noorjahan Panjwani (Tufts University)H-Index: 24
view all 5 authors...
PURPOSE. Corneal neovascularization and scarring commonly lead to significant vision loss. This study was designed to determine whether a small-molecule inhibitor of galectin-3 can inhibit both corneal angiogenesis and fibrosis in experimental mouse models. METHODS. Animal models of silver nitrate cautery and alkaline burn were used to induce mouse corneal angiogenesis and fibrosis, respectively. Corneas were treated with the galectin-3 inhibitor, 33DFTG, or vehicle alone and were processed for ...
18 CitationsSource
#1Yonggang LuH-Index: 4
#2Mingming ZhangH-Index: 1
Last. Jian LiH-Index: 6
view all 9 authors...
8 CitationsSource
#1Vinod Vijay Subhash (NUS: National University of Singapore)H-Index: 6
#2Samantha Shi Min Ling (NUS: National University of Singapore)H-Index: 3
Last. Bow Ho (NUS: National University of Singapore)H-Index: 33
view all 3 authors...
Galectin-3 (Gal-3) is a 尾-galactoside lectin that is upregulated and rapidly secreted by gastric epithelial cells in response to Helicobacter pylori infection. An earlier study reported the involvement of H. pylori cytotoxin-associated gene A (cagA) in the expression of intracellular Gal-3. However, the role of extracellular Gal-3 and its functional significance in H. pylori-infected cells remains uncharacterized. Data presented here demonstrate secretion of Gal-3 is an initial host response eve...
7 CitationsSource
#1Tatsuo Shimura (Fukushima Medical University)H-Index: 22
#2Masahiko Shibata (Saitama Medical University)H-Index: 4
Last. Seiichi Takenoshita (Fukushima Medical University)H-Index: 32
view all 10 authors...
Galectin-3, a 尾-galactoside-binding lectin, exhibits pleiotropic biological functions and has a role as one of the immunological modulators. However, the associations between circulating galectin-3 and immunological, inflammatory and nutritional parameters have not yet been fully elucidated. The serum concentration of galectin-3 was examined in association with interleukin-10 (IL-10), IL-12 and IL17 production, lymphocyte stimulation, neutrophil/lymphocyte ratio (NLR), white blood cell count (WB...
7 CitationsSource
#1Beatriz L贸pez-Melgar (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 10
#2Leticia Fern谩ndez-Friera (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 22
Last. Valentin Fuster MDPhD (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 167
view all 15 authors...
Abstract Introduction Direct quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3DVUS accuracy for plaque volume measurement with special emphasis on small plaques (a hallmark of early atherosclerosis). Methods The in聽vitro study consisted of nine phan...
6 CitationsSource
#1Peter P. Ruvolo (University of Texas MD Anderson Cancer Center)H-Index: 34
Abstract Galectin 3 is a member of a family of 尾-galactoside binding proteins and has emerged as an important regulator of diverse functions critical in cancer biology including apoptosis, metastasis, immune surveillance, molecular trafficking, mRNA splicing, gene expression, and inflammation. Galectin 3's ability to support cancer cell survival by intra-cellular and extra-cellular mechanisms suggests this molecule is an important component of the tumor microenvironment that potentially could be...
48 CitationsSource
Cited By2
Newest
#1Ying-Shuang Li (SDU: Shandong University)H-Index: 1
#2Xiao-Tong Li (SDU: Shandong University)H-Index: 1
Last. Xiu-Li Guo (SDU: Shandong University)H-Index: 14
view all 6 authors...
Abstract The galactoside-binding protein galectin-3 is commonly overexpressed by cancer cells and promotes cancer progression and metastasis. Over the past few years, evidence has emerged that galectin-3 is also overexpressed in several metabolic malfunction conditions such as diabetes, obesity and atherosclerosis and is involved in the regulation of the occurrence and development of these diseases. Recently, Galectin-3 expression is shown also to be associated with glycolysis and mitochondrial ...
1 CitationsSource
#1Qi Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Kanhua Yin (Harvard University)
Last. Zhaohui Ni (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 8 authors...
Source