Downregulation Of Angptl6 Expression By Exercise In Mice And Human

Angiopoietin-like protein 6 (ANGPTL6) has been introduced as an anti-obesity and insulin-sensitizing hepatokine in mice models. But in human studies, paradoxical upregulations of ANGPTL6 were reported in type 2 DM and metabolic syndrome. Although these phenomena have been understood as compensatory ones, regulatory mechanisms still remain unclear. PURPOSE: The objective of this study is to investigate the changes of ANGPTL6 levels by exercise in...