Gain insight into research trends and influential papers with Research Intelligence.
doi.org/10.1016/j.cell.2018.03.051

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

..., David Haussler
131
Cell64.50
Volume: 173, Issue: 6, Pages: 1356 - 1369.e22
Published: May 1, 2018
Abstract
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and is a determinant of neuronal number in the mammalian cortex. We find that three paralogs of human-specific NOTCH2NL are highly expressed in radial glia. Functional analysis reveals that different alleles of NOTCH2NL have varying potencies to enhance Notch signaling by interacting directly...
Paper Fields
Paper Details
Title
Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
DOI
doi.org/10.1016/j.cell.2018.03.051
Published Date
May 1, 2018
Journal
Cell
Volume
173
Issue
6
Pages
1356 - 1369.e22
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.