Postnatal DNA demethylation and its role in tissue maturation.
Abstract
Development in mammals is accompanied by specific de novo and demethylation events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a large percentage of the tissue-specific methylation pattern is generated postnatally. Demethylation in the liver is observed in thousands of enhancer-like sequences associated with genes that undergo activation during the first few weeks of life. Using. conditional gene ablation...
Paper Details
Title
Postnatal DNA demethylation and its role in tissue maturation.
Published Date
May 23, 2018
Journal
Volume
9
Issue
1
Pages
2040 - 2040
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Notes
History