Design of alpha mangostin-loaded chitosan/alginate controlled-release nanoparticles using genipin as crosslinker

α–Mangostin-loaded chitosan/alginate (CS/ALG) nanoparticles cross-linked with genipin (GP) were prepared for oral controlled drug release. A full factorial design was conducted to investigate the effects of the needle gauge, stirring rate and α–mangostin loading on the size of the nanoparticles. In order to provide controlled release, the nanoparticles were modified by crosslinking with GP, and the physical and chemical characteristics of the...