Early life stress impairs contextual threat expression in female, but not male, mice.
Abstract
Early life stress (ELS) is associated with altered processing of threat signals, and increased lifetime risk of anxiety and affective pathology, disorders that disproportionately affect females. We tested the impact of a limited bedding paradigm of ELS (from P4-11) on contextual threat learning, context memory, footshock sensitivity, and anxietylike behavior, in adult male and female mice. To examine contextual threat learning, mice conditioned...
Paper Details
Title
Early life stress impairs contextual threat expression in female, but not male, mice.
Published Date
Aug 1, 2018
Journal
Volume
132
Issue
4
Pages
247 - 257
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