Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice
Abstract
Oxytocin (Oxt) and its receptor (Oxtr) gene system has been implicated in cardiomyogenesis and cardioprotection; however, effects of chronic activation of Oxtr are not known. We generated and investigated transgenic (TG) mice that overexpress Oxtr specifically in the heart.Cardiac-specific overexpression of Oxtr was obtained by having the α-major histocompatibility complex promoter drive the mouse Oxtr gene (α-Mhc-Oxtr). Left ventricular (LV)...
Paper Details
Title
Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice
Published Date
Jul 1, 2018
Journal
Volume
24
Issue
7
Pages
470 - 478
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