Small-Molecule Positive Allosteric Modulators of theβ₂-Adrenoceptor Isolated from DNA-Encoded Libraries

Conventional drug discovery efforts at the β₂-adrenoceptor (β₂AR) have led to the development of ligands that bind almost exclusively to the receptor’s hormone-binding orthosteric site. However, targeting the largely unexplored and evolutionarily unique allosteric sites has potential for developing more specific drugs with fewer side effects than orthosteric ligands. Using our recently developed approach for...