Valproic acid utilization among girls and women in Stockholm: Impact of regulatory restrictions

Summary Objective In November 2014, the European Medicines Agency ( EMA ) strengthened restrictions on the use of valproic acid in girls and women of childbearing potential. The objective of this study was to determine whether there has been a change in initiations of valproic acid treatment to females after the regulatory restrictions and to assess if such changes differed between indications (epilepsy and psychiatric disorder). Methods An...