APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces

Volume: 430, Issue: 17, Pages: 2695 - 2708
Published: Aug 1, 2018
Abstract
The APOBEC3 family of cytosine deaminases catalyzes the conversion of cytosines-to-uracils in single-stranded DNA. Traditionally, these enzymes are associated with antiviral immunity and restriction of DNA-based pathogens. However, a role for these enzymes in tumor evolution and metastatic disease has also become evident. The primary APOBEC3 candidate in cancer mutagenesis is APOBEC3B (A3B) for three reasons: (1) A3B mRNA is upregulated in...
Paper Details
Title
APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces
Published Date
Aug 1, 2018
Volume
430
Issue
17
Pages
2695 - 2708
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