PC224. Application of a Cryogel-Coated Prosthetic Vascular Graft Material for Delivery of Targeted Gene Therapies in a Rabbit Model

The long-term success of prosthetic vascular grafts for revascularization in peripheral arterial disease is limited by the development of anastomotic neointimal hyperplasia (ANIH). We have constructed a bioactive prosthetic graft material (BPGM) by coating polyethylene terephthalate with an antithrombogenic cryogel polymer layer capable of delivering biologic agents to human aortic endothelial cells in vitro. Our goal is to evaluate our hybrid...