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Beneficial role of virgin coconut oil supplementation against acute methotrexate chemotherapy-induced oxidative toxicity and inflammation in rats

Published on Sep 1, 2018in Integrative medicine research
· DOI :10.1016/j.imr.2018.05.001
Ademola C. Famurewa3
Estimated H-index: 3
,
Abiola M. Folawiyo1
Estimated H-index: 1
(Ebonyi State University)
+ 4 AuthorsOpeyemi A. Famurewa1
Estimated H-index: 1
(University of Jos)
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Abstract
Abstract Background Methotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid agent whose efficacy is limited by marked organ toxicities associated with oxidative stress. The study investigated beneficial effect of virgin coconut oil (VCO) supplementation on MTX-induced oxidative stress and inflammation in rats. Methods Rats were divided into 4 groups (n = 6): Control, MTX (20 mg/kg bw), VCO (5%) + MTX and VCO (15%) + MTX. The pre-treatment with VCO for 14 days was followed by single intraperitoneal injection of MTX and the rats were sacrificed after 3 days. Serum activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and levels of reduced glutathione (GSH) and malondialdehyde (MDA) were determined. Interleukin-6 (IL-6), C-reactive protein (CRP) and nitric oxide (NO) levels were also evaluated. Results MTX induced a distinct diminution in serum activities of oxidative stress markers (SOD, CAT, GPx and GSH), while lipid peroxidation considerably increased demonstrated by MDA level. Similarly, levels of IL-6, CRP and NO increased prominently in MTX control rats. The VCO supplementation markedly enhanced resistance to the MTX-induced biochemical alterations in rats. Conclusion VCO can be a useful adjuvant natural product in MTX chemotherapy by reducing oxidative stress and pro-inflammatory responses.
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  • Citations (1)
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References44
Newest
Published on May 4, 2018in Journal of Dietary Supplements
Ademola C. Famurewa3
Estimated H-index: 3
,
Chima A. Ekeleme-Egedigwe2
Estimated H-index: 2
+ 3 AuthorsGoodness C. Ezechukwu1
Estimated H-index: 1
ABSTRACTResearch findings that suggest beneficial health effects of dietary supplementation with virgin coconut oil (VCO) are limited in the published literature. This study investigated the in vivo effects of a 5-week VCO-supplemented diet on lipid profile, hepatic antioxidant status, hepatorenal function, and cardiovascular risk indices in normal rats. Rats were randomly divided into 3 groups: 1 control and 2 treatment groups (10% and 15% VCO-supplemented diets) for 5 weeks. Serum and homogena...
Published on Mar 1, 2018in Journal of the Science of Food and Agriculture2.42
Arunaksharan Narayanankutty6
Estimated H-index: 6
,
Devika Mukundan Palliyil1
Estimated H-index: 1
+ 1 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
Hepatosteatosis, a form of nonalcoholic fatty liver disease (NAFLD), is being increasingly recognized as a major health burden worldwide. Insulin resistance, dyslipidemia and imbalances in adipokine/cytokine interplay are reported to be involved in the onset and progression of this disease. Use of dietary nutraceuticals in prevention and treatment of NAFLD is emerging. Virgin coconut oil (VCO), a fermented product of fresh coconut kernel, has been shown to impede the development of hepatosteatos...
Published on Jul 24, 2017in Toxicology Mechanisms and Methods2.28
Soorya Parathodi Illam4
Estimated H-index: 4
,
Arunaksharan Narayanankutty6
Estimated H-index: 6
,
Achuthan C. Raghavamenon5
Estimated H-index: 5
AbstractVirgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol content (VCOP), the mechanistic basis of which is less explored. Liquid chromatography/mass spectroscopy (LC/MS) analysis of VCOP ...
Published on Mar 1, 2017in Biomedicine & Pharmacotherapy3.74
Ademola C. Famurewa3
Estimated H-index: 3
,
Odomero G. Ufebe2
Estimated H-index: 2
+ 2 AuthorsGodwin S. Obaje1
Estimated H-index: 1
Abstract Background The emerging health benefit of virgin coconut oil (VCO) has been associated with its potent natural antioxidants; however, the antioxidant and hepatoprotective effect of VCO against methotrexate-induced liver damage and oxidative stress remains unexplored. The study explored the antioxidant and hepatoprotective effects of VCO against oxidative stress and liver damage induced by anticancer drug methotrexate (MTX) in rats. Methods Liver damage was induced in Wistar rats pretrea...
Published on Jan 1, 2017in Human & Experimental Toxicology2.17
Yasemin Yuksel5
Estimated H-index: 5
,
Ramazan Yuksel4
Estimated H-index: 4
(Yıldırım Beyazıt University)
+ 4 AuthorsOsman Özcan2
Estimated H-index: 2
(Turgut Özal University)
Objective:This experimental study was conducted to elucidate the possible protective/therapeutic effects of quercetin against methotrexate (Mtx)-induced kidney toxicity with biochemical and histopathological studies.Methods:Twenty-four adult male rats were randomly divided into four groups, as follows: control group (saline intraperitoneally (i.p.), 9 days), Mtx group (20 mg/kg i.p., single dose), Mtx + quercetin group (50 mg/kg quercetin was orally administered 2 days before and 6 days after Mt...
Published on Jul 1, 2016in CA: A Cancer Journal for Clinicians223.68
Giuseppe Curigliano37
Estimated H-index: 37
(IEO: European Institute of Oncology),
Daniela Cardinale31
Estimated H-index: 31
(IEO: European Institute of Oncology)
+ 4 AuthorsCarlo M. Cipolla25
Estimated H-index: 25
(IEO: European Institute of Oncology)
Answer questions and earn CME/CNE Cancer and heart disease are the leading causes of morbidity and mortality in the industrialized world. Modern treatment strategies have led to an improvement in the chances of surviving a diagnosis of cancer; however, these gains can come at a cost. Patients may experience adverse cardiovascular events related to their cancer treatment or as a result of an exacerbation of underlying cardiovascular disease. With longer periods of survival, late effects of cancer...
Published on Jun 12, 2016in Toxicology Mechanisms and Methods2.28
Mina Thabet Kelleni4
Estimated H-index: 4
(Minia University),
Salwa A. Ibrahim7
Estimated H-index: 7
(Minia University),
Aly M. Abdelrahman11
Estimated H-index: 11
(Minia University)
AbstractMethotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid drug whose efficacy is limited by its hepatotoxicity. The aim of this study was to investigate the possible protective role of captopril (100 mg/kg/day, p.o. for seven days), an angiotensin converting enzyme inhibitor, and telmisartan (10 mg/kg/day p.o. for seven days), an angiotensin II receptor blocker with peroxisome proliferative receptor gamma (PPARγ) agonism, in a model of MTX (single dose 20 mg/kg i.p. at the...
Published on Jun 1, 2016in Journal of Oncology Pharmacy Practice1.83
Tracy Wiczer3
Estimated H-index: 3
(OSU: Ohio State University),
Emily Dotson2
Estimated H-index: 2
(OSU: Ohio State University)
+ 2 AuthorsKami J. Maddocks23
Estimated H-index: 23
(OSU: Ohio State University)
IntroductionHigh-dose methotrexate (doses ≥1 g/m2) is a key component of several chemotherapy regimens used to treat patients with leukemia or lymphoma. Despite appropriate precautions with hydration, urine alkalinization, and leucovorin, nephrotoxicity remains a risk which can lead to significant morbidity and mortality. Current reports of risk factors for nephrotoxicity focus on patients with nephrotoxicity with a lack of comparison to those without toxicity. This study aimed to describe the i...
Published on May 11, 2016in PeerJ2.35
Shaobin Gu5
Estimated H-index: 5
(HAUST: Henan University of Science and Technology),
Ying Wu2
Estimated H-index: 2
(HAUST: Henan University of Science and Technology),
Jianbo Yang1
Estimated H-index: 1
(Rice University)
As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a micronucleus assay was employed to estimate the cytoprotective effects of ten kinds of bioactive phytochemicals and their combinations. The results showed that allicin, proanthocyanidins, polyphenols, eleutherosides and isoflavones had higher antimutagen...
Cited By1
Newest
Published on 2019in Basic & Clinical Pharmacology & Toxicology2.45
Suping Xiong1
Estimated H-index: 1
(NCU: Nanchang University),
Dandan Song1
Estimated H-index: 1
(NCU: Nanchang University)
+ 7 AuthorsXiaoning Zhang (NCU: Nanchang University)
Published on Oct 1, 2018in Trends in Food Science and Technology8.52
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Soorya Parathodi Illam4
Estimated H-index: 4
(University of Calicut),
Achuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Abstract Background Edible oils, preferably plant origin are rich sources of fatty acids and other lipophilic antioxidants to the body. Among these, oils derived from the coconut kernel ( Cocos nucifera ) are widely used in India and the Asia Pacific, which includes copra oil (CO), virgin coconut oil (VCO) and refined, bleached and deodorized (RBD) oil. Based on the mode of preparation, their composition and biological effects vary. Scope and approach This review compares the physicochemical and...
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