APOE‐ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

Introduction Although the apolipoprotein E ε4‐allele ( APOE ‐ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB = 48; 38 autopsy‐confirmed; NCT01800214 ) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to...