Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association

Published on Jul 3, 2018in Circulation23.054
· DOI :10.1161/CIR.0000000000000574
Eric B. Rimm171
Estimated H-index: 171
Lawrence J. Appel107
Estimated H-index: 107
+ 6 AuthorsAlice H. Lichtenstein84
Estimated H-index: 84
Since the 2002 American Heart Association scientific statement “Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease,” evidence from observational and experimental studies and from randomized controlled trials continues to emerge to further substantiate the beneficial effects of seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease. A recent American Heart Association science advisory addressed the specific effect of n-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events. This American Heart Association science advisory extends that review and offers further support to include n-3 polyunsaturated fatty acids from seafood consumption. Several potential mechanisms have been investigated, including antiarrhythmic, anti-inflammatory, hematologic, and endothelial, although for most, longer-term dietary trials of seafood are warranted to substantiate the benefit of seafood as a replacement for other important sources of macronutrients. The present science advisory reviews this evidence and makes a suggestion in the context of the 2015–2020 Dietary Guidelines for Americans and in consideration of other constituents of seafood and the impact on sustainability. We conclude that 1 to 2 seafood meals per week be included to reduce the risk of congestive heart failure, coronary heart disease, ischemic stroke, and sudden cardiac death, especially when seafood replaces the intake of less healthy foods.
  • References (88)
  • Citations (44)
📖 Papers frequently viewed together
16 Authors (Theingi Aung, ..., Robert Clarke)
146 Citations
954 Citations
157 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Neal D. Barnard (GW: George Washington University)H-Index: 36
#2Barry M. Popkin (Harvard University)H-Index: 328
Last. Eric L. Ding (Harvard University)H-Index: 68
view all 3 authors...
39 CitationsSource
#1Yoriko Heianza (Tulane University)H-Index: 23
#2Wenjie Ma (Harvard University)H-Index: 11
Last. Lu Qi (Tulane University)H-Index: 76
view all 5 authors...
Background Gut microbial metabolites have been implicated as novel risk factors for cardiovascular events and premature death. The strength and consistency of associations between blood concentrations of the gut microbial metabolites, trimethylamine‐N‐oxide (TMAO) and its precursors, with major adverse cardiovascular events (MACE) or death have not been comprehensively assessed. We quantified associations of blood concentrations of TMAO and its precursors with risks of MACE and mortality. Method...
73 CitationsSource
#1David S. SiscovickH-Index: 117
Last. Dariush MozaffarianH-Index: 122
view all 12 authors...
157 CitationsSource
#1William Cheung (IARC: International Agency for Research on Cancer)H-Index: 10
#2Pekka Keski-Rahkonen (IARC: International Agency for Research on Cancer)H-Index: 7
Last. Augustin Scalbert (IARC: International Agency for Research on Cancer)H-Index: 76
view all 30 authors...
Background: Meat and fish intakes have been associated with various chronic diseases. The use of specific biomarkers may help to assess meat and fish intake and improve subject classification according to the amount and type of meat or fish consumed. Objective: A metabolomic approach was applied to search for biomarkers of meat and fish intake in a dietary intervention study and in free-living subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: In...
46 CitationsSource
#1Mingyang Song (Harvard University)H-Index: 30
#2Teresa T. Fung (Harvard University)H-Index: 45
Last. Edward Giovannucci (Harvard University)H-Index: 182
view all 7 authors...
Importance Defining what represents a macronutritionally balanced diet remains an open question and a high priority in nutrition research. Although the amount of protein may have specific effects, from a broader dietary perspective, the choice of protein sources will inevitably influence other components of diet and may be a critical determinant for the health outcome. Objective To examine the associations of animal and plant protein intake with the risk for mortality. Design, Setting, and Parti...
111 CitationsSource
#1Emily Oken (Harvard University)H-Index: 61
#2Sheryl L. Rifas–Shiman (Harvard University)H-Index: 70
Last. Matthew W. Gillman (Harvard University)H-Index: 108
view all 8 authors...
Abstract Background Few studies of maternal prenatal fish intake have included biomarkers of exposure to mercury, long-chain n-3 fatty acids, and selenium, which are hypothesized to mediate associations with child neurodevelopment. Objectives Examine associations of maternal prenatal fish intake with child neurodevelopment accounting for biomarkers. Methods In 1999–2002 we enrolled pregnant women into the Project Viva cohort. At median 27.9 weeks gestation, we estimated maternal fish intake usin...
26 CitationsSource
#1Ethan M BalkH-Index: 57
#2Gaelen P AdamsH-Index: 1
Last. Thomas A TrikalinosH-Index: 57
view all 13 authors...
BACKGROUND: The effect and association of omega-3 fatty acids (n-3 FA) intake and biomarker levels with cardiovascular (CV) clinical and intermediate outcomes remains controversial. We update prior Evidence Reports of n-3 FA and clinical and intermediate CV disease (CVD) outcomes. OBJECTIVES: Evaluate the effect of n-3 FA on clinical and selected intermediate CV outcomes and the association of n-3 FA intake and biomarkers with CV outcomes. The n-3 FA under review include eicosapentaenoic acid (E...
11 CitationsSource
#1Liana C. Del Gobbo (Stanford University)H-Index: 14
#2Fumiaki Imamura (Medical Research Council)H-Index: 31
Last. Dariush Mozaffarian (Tufts University)H-Index: 122
view all 49 authors...
IMPORTANCE The role of omega-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported cons ...
126 CitationsSource
#1Colin D. Rehm (Tufts University)H-Index: 29
#2José L. Peñalvo (Tufts University)H-Index: 29
Last. Dariush Mozaffarian (Tufts University)H-Index: 122
view all 4 authors...
Importance Most studies of US dietary trends have evaluated major macronutrients or only a few dietary factors. Understanding trends in summary measures of diet quality for multiple individual foods and nutrients, and the corresponding disparities among population subgroups, is crucial to identify challenges and opportunities to improve dietary intake for all US adults. Objective To characterize trends in overall diet quality and multiple dietary components related to major diseases among US adu...
160 CitationsSource
#1Paul J. Nestel (Baker IDI Heart and Diabetes Institute)H-Index: 73
#2Peter M. Clifton (UniSA: University of South Australia)H-Index: 73
Last. Beth Thomas (National Heart Foundation of Australia)H-Index: 27
view all 7 authors...
Background The National Heart Foundation of Australia (NHFA) 2008 review on omega-3 long-chain polyunsaturated fatty acids (LCPUFA) made recommendations with respect to supplementation for primary and secondary prevention of cardiovascular disease. Since then, new findings have been published regarding the relationship between omega-3 polyunsaturated fatty acids, including supplementation, and cardiovascular health. Methods A literature search was undertaken in PubMed and Medline, for literature...
83 CitationsSource
Cited By44
#1J. Whelan (UT: University of Tennessee)
#2Jay Whelan (UT: University of Tennessee)H-Index: 25
Abstract The purpose of this research was to explore various allometric scaling models for dietary nutrients to improve translational validity between preclinical experimental rodent models and humans, focusing on polyunsaturated fats. Currently, there is no authoritative document that provides standardized guidelines for which dietary designs can be based on to improve translational fidelity between species. This paper reviews the challenges of using a rodent model, the major allometric scaling...
#1David C. Love (Johns Hopkins University)H-Index: 21
#2Frank Asche (UF: University of Florida)H-Index: 50
Last. Roni A. Neff (Johns Hopkins University)H-Index: 17
view all 8 authors...
The aim of this study was to explore United States (U.S.) seafood consumption patterns, food sourcing, expenditures, and geography of consumption. We analyzed seafood intake and food sourcing using the National Health and Nutrition Examination Survey (NHANES) cycles 2007–2008 to 2015–2016 for US adults ≥19 years old (n = 26,743 total respondents; n = 4957 respondents consumed seafood in the past 24 h). Seafood expenditures were extrapolated by combining NHANES with three other public datasets. U...
#1Francisco Gomez-Delgado (UCO: University of Córdoba (Spain))H-Index: 13
#2Niki Katsiki (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 30
Last. Pablo Perez-Martinez (UCO: University of Córdoba (Spain))H-Index: 25
view all 4 authors...
Cardiovascular disease (CVD) remains the first cause of mortality in Western countries. Among cardiometabolic risk factors, dyslipidemia, and especially high low-density lipoprotein cholesterol (LD...
#1Haibin Sun (Ocean University of China)
#2Yu Song (Ocean University of China)H-Index: 3
Last. Changhu Xue (Ocean University of China)H-Index: 30
view all 9 authors...
Abstract In this study, comprehensive lipid composition in the muscle tissue of four popularly consumed shrimp species was determined using ultra-performance liquid chromatography-triple time-of-flight tandem mass spectrometry (UPLC−Triple TOF−MS/MS). About 600 molecules from 14 types of lipids were characterized and quantified. Phospholipids (PLs) were the main component in all four shrimp species (51.4–71.0% of total lipids). Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were the ...
#1Ursula Strandberg (RyeU: Ryerson University)H-Index: 14
Last. Michael T. Arts (RyeU: Ryerson University)H-Index: 33
view all 3 authors...
Abstract Contaminants and essential omega-3 fatty acids were analyzed in the fillets of 15 fish species from lakes Superior and Huron in order to estimate the risks and benefits of fish consumption. Additionally, literature data from lakes Ontario and Erie fish were used to provide an overall assessment for 24 fish species from the Canadian waters of the Great Lakes. The consumption advisory (based on contaminant levels) and EPA + DHA content (eicosapentanoic + docosahexanoic acid) were consider...
#1Ruyuan Zhang (ZJU: Zhejiang University)
#2Tarun Belwal (ZJU: Zhejiang University)H-Index: 10
Last. Zisheng Luo (ZJU: Zhejiang University)H-Index: 27
view all 6 authors...
Abstract Many bioactive food ingredients were encapsulated in different forms to improve their stability and bioavailability. Emulsions have showed excellent properties in encapsulation, controlled release, and targeted delivery of bioactives. Polysaccharides are widely available and have different structures with different advantages including non-toxic, easily digested, biocompatible and can keep stable over a wide range of pH and temperatures. In this review, the most common polysaccharides a...
#1Clemens von Schacky (LMU: Ludwig Maximilian University of Munich)H-Index: 30
The omega-3 index, the percentage of EPA plus DHA in erythrocytes (measured by standardised analysis), represents a human body's status in EPA and DHA. An omega-3 index is measured in many laboratories around the world; however, even small differences in analytical methods entail large differences in results. Nevertheless, results are frequently related to the target range of 8-11 %, defined for the original and scientifically validated method (HS-Omega-3 Index(R)), raising ethical issues, and c...
#1Chao Gao (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 1
#2Yang Liu (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 1
Last. Zhu Wang (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 3
view all 11 authors...
BACKGROUND: Previous studies have yielded inconsistent findings on the role of fish oil in type 2 diabetes mellitus (T2DM). We systematically summarized the available evidence from randomized controlled trials (RCT) and aimed to investigate the effects of fish oil supplementation on glucose control and lipid levels among patients with T2DM. METHODS: A comprehensive literature search was performed in electronic databases (PubMed, ProQuest, Cochrane Library, CNKI, VIP, and Wanfang) to identify all...
1 CitationsSource
#1Francesco Violi (Sapienza University of Rome)H-Index: 64
#2Daniele Pastori (Sapienza University of Rome)H-Index: 23
Last. Roberto Carnevale (Sapienza University of Rome)H-Index: 32
view all 4 authors...
Previous studies reported an inverse association between healthy dietary patterns (such as Mediterranean diet) and the incidence of cardiovascular events. As the mechanism accounting for cardiovascular disease is prevalently due to the atherothrombosis, where a pivotal role is played by platelet activation, it would be arguable that diets with protective effects against cardiovascular disease exert an anti-atherothrombotic effect via inhibition of platelet activation. There are several and spars...