Reproductive Hormones and Subclinical Cardiovascular Disease in Midlife Women

Context Reproductive hormones are important to the pathophysiology of cardiovascular disease (CVD) in women. However, standard estradiol (E2) and testosterone (T) assays lack sensitivity at the levels of postmenopausal women. Objective Investigate relations of mass spectrometry–assessed estrone (E1), E2, and T and SHBG and subclinical CVD in women. Design, Setting, and Participants Three hundred and four perimenopausal and postmenopausal women...