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Reliability and main findings of the flexible endoscopic evaluation of swallowing-Tensilon test in patients with myasthenia gravis and dysphagia.

Published on Oct 1, 2018in European Journal of Neurology4.387
· DOI :10.1111/ene.13688
Sun Im10
Estimated H-index: 10
(Catholic University of Korea),
Sonja Suntrup-Krueger7
Estimated H-index: 7
(WWU: University of Münster)
+ 5 AuthorsTobias Warnecke24
Estimated H-index: 24
(WWU: University of Münster)
Abstract
  • References (13)
  • Citations (2)
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References13
Newest
#1Tobias WarneckeH-Index: 24
#2Inga SuttrupH-Index: 7
Last. Rainer DziewasH-Index: 34
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Abstract Background It is still controversially discussed whether central dopaminergic stimulation improves swallowing ability in Parkinson's disease (PD). We evaluated the effect of oral levodopa application on dysphagia in advanced PD patients with motor fluctuations. Methods In 15 PD patients (mean age 71.93 ± 8.29 years, mean disease duration 14.33 ± 5.94 years) with oropharyngeal dysphagia and motor fluctuations endoscopic swallowing evaluation was performed in the off state and on state co...
24 CitationsSource
#1Paul D. Neubauer (Yale University)H-Index: 4
#2Alfred W Rademaker (NU: Northwestern University)H-Index: 91
Last. Steven B. Leder (Yale University)H-Index: 32
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The Yale Pharyngeal Residue Severity Rating Scale was developed, standardized, and validated to provide reliable, anatomically defined, and image-based assessment of post-swallow pharyngeal residue severity as observed during fiberoptic endoscopic evaluation of swallowing (FEES). It is a five-point ordinal rating scale based on residue location (vallecula and pyriform sinus) and amount (none, trace, mild, moderate, and severe). Two expert judges reviewed a total of 261 FEES evaluations and selec...
32 CitationsSource
#1Jan Kottner (Charité)H-Index: 27
#2Laurent AudigéH-Index: 5
Last. David L. Streiner (U of T: University of Toronto)H-Index: 85
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Abstract Objective Results of reliability and agreement studies are intended to provide information about the amount of error inherent in any diagnosis, score, or measurement. The level of reliability and agreement among users of scales, instruments, or classifications is widely unknown. Therefore, there is a need for rigorously conducted interrater and intrarater reliability and agreement studies. Information about sample selection, study design, and statistical analysis is often incomplete. Be...
683 CitationsSource
#1Tobias WarneckeH-Index: 24
#2Inga K. TeismannH-Index: 21
Last. Rainer DziewasH-Index: 34
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Background Dysphagia is a common symptom in myasthenia gravis (MG). Clinical examination alone fails to detect and grade myasthenic dysphagia sufficiently. For a more precise examination of swallowing function in myasthenia gravis additional technical tools are necessary.
22 CitationsSource
AbstractMyasthenia gravis (MG) is clinically characterized by fatigable muscle weakness. Because dysphagia is a frequent and important symptom in patients with MG, an adequate diagnostic approach is mandatory. In this article, we describe a standardized endoscopic examination called “fatigable swall
6 CitationsSource
Three patients are described who had dysphagia as the sole manifestation of myasthenia gravis. Severity ranged from the need to be fed by nasogastric tube to moderate dysphagia requiring only diet change. Oesophageal manometry was carried out in two patients and showed generalised weakness of peristaltic contractions which included the smooth muscle part of the oesophagus. These disturbances worsened with repeated swallows. They were partly reversed by intravenous edrophonium and by rest. Repeti...
27 CitationsSource
#1John Keesey (UCLA: University of California, Los Angeles)H-Index: 18
Myasthenia gravis (MG) is a syndrome of fluctuating skeletal muscle weakness that worsens with use and improves with rest. Eye. facial. oropharyngeal, axial, and limb muscles may be involved in varying combi­ nations and degrees of severity. Its etiology is heterogeneous. divided initially between those rare congenital myasthenic syndromes. which are genetic, and the bulk of MG. which is acquired and autoimmune. The autoimmune conditions are divided in turn between those that possess measurable ...
175 CitationsSource
Cholinesterase inhibitors (CEIs) have been known to improve strength in patients with myasthenia gravis (MG) since the 1930s, and have been used as a diagnostic test since the early 1950s. The following review summarizes the history of edrophonium usage in myasthenia gravis, reviews the literature with regard to the method of performing the edrophonium test, and discusses the available information regarding sensitivity and specificity of the test with respect to diagnosis of MG.
58 CitationsSource
#1Angela Colton-Hudson (London Health Sciences Centre)H-Index: 2
#2Wilma J. Koopman (London Health Sciences Centre)H-Index: 3
Last. Michael W. Nicolle (London Health Sciences Centre)H-Index: 8
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36 CitationsSource
#1Giovanni Pavesi (University of Parma)H-Index: 19
#2Luigi Cattaneo (University of Parma)H-Index: 26
Last. Domenico Mancia (University of Parma)H-Index: 19
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Abstract Objective : (1) to develop a method for masseteric repetitive nerve stimulation (RNS) and to obtain normative data for amplitude and area decrement of the muscle (M) response. (2) To investigate myasthenia gravis (MG) patients with masseteric RNS. Masticatory muscles are frequently affected in MG, but no RNS test is available to investigate this district. Methods : Fifteen healthy subjects and 17 MG patients were examined. The masseteric nerve was stimulated by a monopolar needle (catho...
28 CitationsSource
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#1Eliana B. Souto (UC: University of Coimbra)H-Index: 46
#2Bernardo Lima (UC: University of Coimbra)H-Index: 1
Last. Amélia M. Silva (UTAD: University of Trás-os-Montes and Alto Douro)H-Index: 23
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Abstract Myasthenia Gravis (MG) – an autoimmune neuromuscular disease – is known by the production of autoantibodies against components of the neuromuscular junction mainly to the acetylcholine receptor, which cause the destruction and compromises the synaptic transmission. This disease is characterized by fluctuating and fatigable muscle weakness, becoming more intensive with activity, but with an improvement under resting. There are many therapeutic strategies used to alleviate MG symptoms, ei...
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#1Bendix LabeitH-Index: 1
#2Paul MuhleH-Index: 7
Last. Tobias WarneckeH-Index: 24
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Dysphagia can be predominant or sole symptom of myositis. However, diagnostic evaluation is difficult in such cases. Here, we present evidence for dysphagia as sole manifestation of Jo-1 associated myositis. A 77-year-old patient suffering from isolated dysphagia was assessed by flexible endoscopic evaluation of swallowing, videofluoroscopy, high resolution oesophageal manometry, whole body muscle MRI, electroneurographic and electromyographic examination, cerebrospinal fluid analysis, screening...
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