Reliability and main findings of the flexible endoscopic evaluation of swallowing-Tensilon test in patients with myasthenia gravis and dysphagia.

Published on Oct 1, 2018in European Journal of Neurology4.387
· DOI :10.1111/ene.13688
Sun Im10
Estimated H-index: 10
(Catholic University of Korea),
Sonja Suntrup-Krueger7
Estimated H-index: 7
(WWU: University of Münster)
+ 5 AuthorsTobias Warnecke24
Estimated H-index: 24
(WWU: University of Münster)
  • References (13)
  • Citations (2)
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Background Dysphagia is a common symptom in myasthenia gravis (MG). Clinical examination alone fails to detect and grade myasthenic dysphagia sufficiently. For a more precise examination of swallowing function in myasthenia gravis additional technical tools are necessary.
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AbstractMyasthenia gravis (MG) is clinically characterized by fatigable muscle weakness. Because dysphagia is a frequent and important symptom in patients with MG, an adequate diagnostic approach is mandatory. In this article, we describe a standardized endoscopic examination called “fatigable swall
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Three patients are described who had dysphagia as the sole manifestation of myasthenia gravis. Severity ranged from the need to be fed by nasogastric tube to moderate dysphagia requiring only diet change. Oesophageal manometry was carried out in two patients and showed generalised weakness of peristaltic contractions which included the smooth muscle part of the oesophagus. These disturbances worsened with repeated swallows. They were partly reversed by intravenous edrophonium and by rest. Repeti...
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Myasthenia gravis (MG) is a syndrome of fluctuating skeletal muscle weakness that worsens with use and improves with rest. Eye. facial. oropharyngeal, axial, and limb muscles may be involved in varying combi­ nations and degrees of severity. Its etiology is heterogeneous. divided initially between those rare congenital myasthenic syndromes. which are genetic, and the bulk of MG. which is acquired and autoimmune. The autoimmune conditions are divided in turn between those that possess measurable ...
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Cholinesterase inhibitors (CEIs) have been known to improve strength in patients with myasthenia gravis (MG) since the 1930s, and have been used as a diagnostic test since the early 1950s. The following review summarizes the history of edrophonium usage in myasthenia gravis, reviews the literature with regard to the method of performing the edrophonium test, and discusses the available information regarding sensitivity and specificity of the test with respect to diagnosis of MG.
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Abstract Myasthenia Gravis (MG) – an autoimmune neuromuscular disease – is known by the production of autoantibodies against components of the neuromuscular junction mainly to the acetylcholine receptor, which cause the destruction and compromises the synaptic transmission. This disease is characterized by fluctuating and fatigable muscle weakness, becoming more intensive with activity, but with an improvement under resting. There are many therapeutic strategies used to alleviate MG symptoms, ei...
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