CLIP-related methodologies and their application to retrovirology
Abstract
Virtually every step of HIV-1 replication and numerous cellular antiviral defense mechanisms are regulated by the binding of a viral or cellular RNA-binding protein (RBP) to distinct sequence or structural elements on HIV-1 RNAs. Until recently, these protein-RNA interactions were studied largely by in vitro binding assays complemented with genetics approaches. However, these methods are highly limited in the identification of the relevant...
Paper Details
Title
CLIP-related methodologies and their application to retrovirology
Published Date
May 2, 2018
Journal
Volume
15
Issue
1
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