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Lifetime Smoking History and Risk of Lung Cancer: Results From the Framingham Heart Study.

Published on May 16, 2018in Journal of the National Cancer Institute10.211
· DOI :10.1093/jnci/djy041
Hilary A. Tindle29
Estimated H-index: 29
(VUMC: Vanderbilt University Medical Center),
Meredith S. Duncan7
Estimated H-index: 7
(BU: Boston University)
+ 4 AuthorsMatthew S. Freiberg30
Estimated H-index: 30
(VUMC: Vanderbilt University Medical Center)
Abstract
  • References (36)
  • Citations (9)
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Rationale: Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening program.Objectives: To quantify the effects of smoking history and abstinence on mortality in high-risk individuals who participated in the NLST (National Lung Screening Trial).Me...
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ObjectiveCurrent United States recommendations for low-dose computed tomography (LDCT) lung cancer screening limit eligibility to ever-smokers with 30+ pack-years, with former smokers eligible only within 15 years of quitting. The 15 year limit is partly based on perceived decreases in lung cancer risk as years since quitting (YSQ) increase. We examine the relationship between lung cancer risk and YSQ among 30+ pack-year former smokers.MethodsIn the Prostate, Lung, Colorectal, and Ovarian trial,...
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AbSTRACT Aims and background: The aims of this paper are to compute the risks of dying of ischemic heart disease (IHD), lung cancer (LC), stroke, and chronic obstructive pulmonary disease (COPD) for Italian smokers by gender, age and daily number of cigarettes smoked, and to estimate the benefit of stopping smoking in terms of risk reduction.Methods: Life tables by sex and smoking status were computed for each smoking-related disease based on Italian smoking data, and risk charts with 10-year pr...
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Thanks to recent evidence that screening with low-dose computed tomography reduces lung-cancer mortality, at-risk U.S. patients 55 to 77 years of age are now eligible for a screening benefit under Medicare, while further data are collected and assessed.
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#1Catherine A. Wassenaar (U of T: University of Toronto)H-Index: 6
#2Yuanqing Ye (University of Texas MD Anderson Cancer Center)H-Index: 37
Last. Rachel F. Tyndale (U of T: University of Toronto)H-Index: 58
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We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk and CYP2A6 gene variants differ significantly between European and African ancestry populations. Herein, African American ever-smokers, drawn from two independent lung cancer case-control studies, ...
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Background Lung cancer risks at which individuals should be screened with computed tomography (CT) for lung cancer are undecided. This study's objectives are to identify a risk threshold for selecting individuals for screening, to compare its efficiency with the U.S. Preventive Services Task Force (USPSTF) criteria for identifying screenees, and to determine whether never-smokers should be screened. Lung cancer risks are compared between smokers aged 55–64 and ≥65–80 y. Methods and Findings Appl...
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DESCRIPTION: Update of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for lung cancer. METHODS: The USPSTF reviewed the evidence on the efficacy of low-dose computed tomography, chest radiography, and sputum cytologic evaluation for lung cancer screening in asymptomatic persons who are at average or high risk for lung cancer (current or former smokers) and the benefits and harms of these screening tests and of surgical resection of early-stage non-small cell lu...
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Data Synthesis: Four trials reported results of LDCT screening among patients with smoking exposure. One large good-quality trial reported that screening was associated with significant reductions in lung cancer (20%) and all-cause (6.7%) mortality. Three small European trials showed no benefit of screening. Harms included radiation exposure, overdiagnosis, and a high rate of falsepositive findings that typically were resolved with further imaging. Smoking cessation was not affected. Incidental ...
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Background In the National Lung Screening Trial (NLST), screening with low-dose computed tomography (CT) resulted in a 20% reduction in lung-cancer mortality among participants between the ages of 55 and 74 years with a minimum of 30 pack-years of smoking and no more than 15 years since quitting. It is not known whether the benefits and potential harms of such screening vary according to lung-cancer risk. Methods We assessed the variation in efficacy, the number of false positive results, and th...
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Abstract In this study carboxymethyl starch grafted poly(methacrylic acids) (CMS-g-PMAAs) were synthesized by treating carboxymethyl starch with methacrylic acid in the presence of initiator potassium persulfate (KPS). The modified starches were characterized by proton nuclear magnetic resonance (1H NMR) and fourier-transform infrared (FT-IR) spectroscopy. The crystallinity of the modified starches was analyzed by x-ray diffraction (XRD) while thermal properties of the modified starches were fou...
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PURPOSE OF REVIEW: We summarize recent literature on the contribution of substance use and depression to non-AIDS-related comorbidities. Discussion of recent randomized clinical trials and implementation research to curtail risk attributed to each behavioral health issue is provided. RECENT FINDINGS: Smoking, unhealthy alcohol use, opioid use, and depression are common among PWH and individually contribute to increased risk for non-AIDS-related comorbidities. The concurrence of these conditions ...
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Lung cancer is the leading cause of cancer mortality in the United States. Certain groups are at increased risk of developing lung cancer and experience greater morbidity and mortality compared to ...
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