The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice

TGR5 (also known as G protein–coupled bile acid receptor 1, GPBAR1) is a G protein–coupled bile acid receptor that is expressed in many diverse tissues. TGR5 is involved in various metabolic processes, including glucose metabolism and energy expenditure; however, TGR5's function in skeletal muscle is not fully understood. Using both gain- and loss-of-function mouse models, we demonstrate here that Tgr5 activation promotes muscle cell...