Redox Pathways as Drug Targets in Microaerophilic Parasites

Microaerophilic parasites, such as Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia account for hundreds of millions of annual infections worldwide. These organisms are susceptible to oxygen because molecular oxygen and several of its derivatives deactivate essential proteins, such as pyruvate:ferredoxin oxidoreductase and ferredoxin. In the body, microaerophilic parasites can be exposed to molecular oxygen and reactive oxygen...