Genetic compensation triggered by mutant mRNA degradation

Nature64.80
Volume: 568, Issue: 7751, Pages: 193 - 197
Published: Apr 3, 2019
Abstract
Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation, a process by which related gene(s) are upregulated independently of protein feedback loops. However, the prevalence of transcriptional adaptation and its underlying molecular mechanisms are...
Paper Details
Title
Genetic compensation triggered by mutant mRNA degradation
Published Date
Apr 3, 2019
Journal
Volume
568
Issue
7751
Pages
193 - 197
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