A systematic review on the frequency of BRCA promoter methylation in breast and ovarian carcinomas of BRCA germline mutation carriers: Mutually exclusive, or not?

Volume: 127, Pages: 29 - 41
Published: Jul 1, 2018
Abstract
A considerable number of breast and ovarian carcinomas are due to underlying BRCA gene aberrations. Of these, BRCA germline mutations and BRCA promoter methylation are thought to be mutually exclusive, which could be exploited in clinical practice. However, this paradigm has not been studied extensively and systematically.To systematically investigate to what extent BRCA promoter methylation has been reported in breast and ovarian carcinomas of...
Paper Details
Title
A systematic review on the frequency of BRCA promoter methylation in breast and ovarian carcinomas of BRCA germline mutation carriers: Mutually exclusive, or not?
Published Date
Jul 1, 2018
Volume
127
Pages
29 - 41
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