Higher‐order structure and conformational change in biopharmaceuticals

The higher order structure (HOS) of protein biopharmaceuticals is critical for biological and pharmacological function. Slight changes in HOS can impact product efficacy and quality, and therefore must be characterised. The technology and techniques available for HOS characterisation has advanced in recent years. Although methods such as the low‐resolution technique circular dichroism (CD) and the labour‐intensive but high‐resolution technique...