Reduced oxidative capacity in macrophages results in systemic insulin resistance

Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 ( Crif1 ), an essential mitoribosomal factor involved in biogenesis of OxPhos...