Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy

Maternal hyperglycemia during pregnancy is associated with excess fetal growth and adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may underlie these associations. We performed an epigenome-wide association study (>850,000 CpG sites) of term placentas and prenatal maternal glycemic response 2-h post oral glucose challenge at 24–30 weeks of gestation among 448 mother-infant pairs. Maternal 2-h glycemia...