Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents

Published on Aug 1, 2018in Materials Science and Engineering: C4.959
· DOI :10.1016/j.msec.2018.04.020
Ampornphan Siriviriyanun6
Estimated H-index: 6
(NTUST: National Taiwan University of Science and Technology),
Ya-Ju Tsai2
Estimated H-index: 2
(NTUST: National Taiwan University of Science and Technology)
+ 7 AuthorsLip Yong Chung19
Estimated H-index: 19
(UM: University of Malaya)
Abstract In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug loading on GO-CD-DEN increased in the order: DOX
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