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Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents

Published on Aug 1, 2018in Materials Science and Engineering: C4.959
· DOI :10.1016/j.msec.2018.04.020
Ampornphan Siriviriyanun6
Estimated H-index: 6
(NTUST: National Taiwan University of Science and Technology),
Ya-Ju Tsai2
Estimated H-index: 2
(NTUST: National Taiwan University of Science and Technology)
+ 7 AuthorsLip Yong Chung19
Estimated H-index: 19
(UM: University of Malaya)
Sources
Abstract
Abstract In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug loading on GO-CD-DEN increased in the order: DOX
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References45
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A combination therapy has gained more attention for the treatment of cancer dieases. In this study, a versatile reduced graphene oxide (rGO) based drug delivery system (DDS) was developed for the combination treatment of chemophotodynamic cancer therapy. The reduced graphene oxide surface decorated with magnetic nanoparticles (MNPs) and camptothecin (CPT) chemo drug. The photosensitizer of 4-hydroxy coumarin (4-HC) was cross-linked with rGO by using allylamine (AA) linker. The CPT loaded MrGO-AA...
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