Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation
Abstract
The focus of Alzheimer’s disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. Due to morphological differences in brain structure in the DS population, special consideration must be given to processing pipelines and...
Paper Details
Title
Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation
Published Date
May 11, 2018
Journal
Volume
13
Issue
2
Pages
345 - 353
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