Enhancing the Translational Capacity of E. coli by Resolving the Codon Bias
Abstract
Escherichia coli is a well-established and popular host for heterologous expression of proteins. The preference in the choice of synonymous codons (codon bias), however, might differ for the host and the original source of the recombinant protein, constituting a potential bottleneck in production. Codon choice affects the efficiency of translation by a complex and poorly understood mechanism. The availability of certain tRNA species is one of...
Paper Details
Title
Enhancing the Translational Capacity of E. coli by Resolving the Codon Bias
Published Date
Oct 23, 2018
Journal
Volume
7
Issue
11
Pages
2656 - 2664
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