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Vitamin D Deficiency is not Associated with Fatty Liver in a Mexican Population

Published on May 1, 2018in Annals of Hepatology1.895
· DOI :10.5604/01.3001.0011.7386
Fabiola López-Bautista2
Estimated H-index: 2
,
Carlos Posadas-Romero26
Estimated H-index: 26
+ 7 AuthorsRosalinda Posadas-Sánchez15
Estimated H-index: 15
Abstract
Abstract Introduction and aim. Association of vitamin D deficiency (VDD) with fatty liver (FL) disease is controversial. The purpose of this study was to analyze the association of VDD with FL. Material and methods. Cross-sectional study. Data on cardiovascular risk factors, medications, alcohol intake, smoking, diet, and physical activity were obtained. Biochemical, anthropometric, and blood pressure variables were measured. The 25-hydroxyvitamin D (25(OH)D) was quantified through chemoluminescence. The presence of FL, defined as a liver/spleen attenuation index lower than 1.0, was identified through computed axial tomography (CAT). Results. The study included 1,467 subjects (49.7% men) with a mean age of 53.3 ± 9.3 years and BMI of 28.3 ± 4.0 kg/m 2 . Only 11% had optimum values of vitamin D, and 25(OH)D concentration was lower in participants with FL. Multivariate logistic regression models, adjusted for age, gender, BMI, sampling season, glucose, total cholesterol, triglycerides, HOMA-IR, hs-CRP, ALT, AST, and elevated VAT, revealed an association between FL and vitamin D (VD) insufficiency (RM 1.61 [0.99-2.61]) and with VDD (RM 1.68 [1.02-2.77]); however, statistical significance was lost when including caloric consumption and physical activity in the model. Conclusions. In Mexican adults, deficient VD concentration and FL were not independently associated of caloric consumption and physical activity.
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References32
Newest
Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis
18 CitationsSource
#1Hualing Zhai (SJTU: Shanghai Jiao Tong University)H-Index: 11
#2Ningjian Wang (SJTU: Shanghai Jiao Tong University)H-Index: 13
Last. Yingli Lu (SJTU: Shanghai Jiao Tong University)H-Index: 16
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Abstract Recent studies have suggested an association between vitamin D and non-alcoholic fatty liver disease (NAFLD); however, some results are subject to debate. This study was carried out to evaluate the correlation between NAFLD and vitamin D in men and women in East China. The data were obtained from a cross-sectional study that focused on the health and metabolic status of adults in sixteen areas of East China. According to ultrasonic assessments, the patients were divided into normal and ...
26 CitationsSource
Obesity is an important risk factor for non-alcoholic fatty liver disease. Few studies have evaluated the association between vitamin D and non-alcoholic fatty liver disease in obese children. Therefore, we conducted a study to examine the relationship of vitamin D levels and hepatosteatosis in obese children.One hundred and eleven children with obesity participated in this study. Hepatosteatosis was diagnosed and graded using ultrasonography in all patients. Study participants were divided base...
4 CitationsSource
#1Sanjaya K. Satapathy (UT: University of Tennessee)H-Index: 14
#2Arun J. Sanyal (VCU: Virginia Commonwealth University)H-Index: 102
The epidemic of obesity has resulted in a parallel incremental burden of nonalcoholic fatty liver disease (NAFLD) worldwide. Nonalcoholic fatty liver disease includes a spectrum of liver disease that ranges from simple fat accumulation in the liver to necroinflammation, fibrosis, cirrhosis, and hepatocellular carcinoma, which in essence represent the stages of the natural history of NAFLD. The rising prevalence of NAFLD globally may be accounted for by changes in dietary habits and an increase i...
160 CitationsSource
#2Stephanie H. Abrams (BCM: Baylor College of Medicine)H-Index: 15
Last. Ann O. Scheimann (Johns Hopkins University)H-Index: 18
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Background In adults, vitamin D deficiency is common in patients with nonalcoholic fatty liver disease (NAFLD) and has been associated with the severity of histology. There are known differences between adult and pediatric NAFLD, with little data regarding the relationship between vitamin D and pediatric NAFLD.
22 CitationsSource
#1Fernando Bril (UF: University of Florida)H-Index: 16
#2Maryann Maximos (UF: University of Florida)H-Index: 6
Last. Kenneth CusiH-Index: 49
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Background & Aims The role of plasma vitamin D deficiency in the development of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) remains poorly understood. Previous studies have suggested a role for vitamin D deficiency in the pathogenesis of NAFLD/NASH, but they have been rather small, and/or NAFLD was diagnosed using only aminotransferases or liver ultrasound. This study aimed to assess the role of vitamin D deficiency in relationship to liver fat accumulation and severity ...
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Background: The association of subclinical hypothyroidism (SCH) with insulin resistance, metabolic syndrome (MS), and coronary atherosclerosis is uncertain. Objective: To investigate the role of increased intrahepatic fat in the association of SCH with insulin resistance, MS, and coronary atherosclerosis. Design, patients, and methods: We conducted a cross-sectional study in a sample of 753 subjects (46% males) aged 35‐70 years with no history of diabetes, renal, hepatic, thyroid, or coronary he...
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Introduction. Individuals with fatty liver (FL) have an increased risk of coronary artery disease (CAD) probably due to its association with cardiometabolic risk factors (CMRF). Objective. To know the prevalence of FL and analyze its association with CMRF and subclinical atherosclerosis, in a sample of Mexican Mestizo population. Material and methods. This study included 846 subjects from the Genetic of Atherosclerosis Disease (GEA) study (53 ± 9 years, 50.7% women) without diabetes and no perso...
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#1Ji A Seo (KU: Korea University)H-Index: 34
#2Chai Ryoung Eun (KU: Korea University)H-Index: 6
Last. Nan-Hui Kim (KU: Korea University)H-Index: 40
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Objective To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and nonalcoholic fatty liver disease (NAFLD) independent of visceral obesity in Koreans and to examine whether the associations differ according to the presence of diabetes or insulin resistance. Research Design and Methods A total of 1081 adults were enrolled from a population-based cohort in Ansan city. Serum 25(OH)D concentrations were measured in all subjects. Insulin resistance was measured by homeos...
28 CitationsSource
#1Amy K. Kasahara (UCI: University of California, Irvine)H-Index: 1
#2Ravinder Jit Singh (Mayo Clinic)H-Index: 57
Last. Andrew Noymer (UCI: University of California, Irvine)H-Index: 11
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Vitamin D is an important micronutrient for health. Hypovitaminosis D is thought to play a role in the seasonality of a number of diseases and adverse health conditions. To refine hypotheses about the links between vitamin D and seasonal diseases, good estimates of the cyclicality of serum vitamin D are necessary. The objective of this study is to describe quantitatively the cyclicality of 25-hydroxyvitamin D (25OHD) in the United States. We provide a statistical analysis with weekly time resolu...
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#1Salwa Seddik Hosny (Ain Shams University)H-Index: 1
#2Hanan Mahmoud Ali (Ain Shams University)
Last. Mohamed Hesham El Ghannam (Ain Shams University)
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Abstract Background Non-alcoholic fatty liver disease (NAFLD) is increasing recently due to increasing the prevalence of obesity. Insulin resistance (IR) is the mutual pathological cause for both T2DM and NAFLD. Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR). Aim Assessment of relationship between Total vitamin D level and NAFLD a sample of Egyptian patients with and without T2DM. Methods The curren...
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