Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain
Abstract
Type 2 diabetes is a complex disorder affected by multiple genes and the environment. Our laboratory has shown that in response to a glucose challenge, two-pore channel 2 ( Tpcn2) knockout mice exhibit a decreased insulin response but normal glucose clearance, suggesting they have improved insulin sensitivity compared with wild-type mice. We tested the hypothesis that improved insulin sensitivity in Tpcn2 knockout mice would protect against the...
Paper Details
Title
Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain
Published Date
Aug 1, 2018
Journal
Volume
50
Issue
8
Pages
605 - 614
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