Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
Abstract
Adenine base editors (ABEs) composed of an engineered adenine deaminase and the Streptococcus pyogenes Cas9 nickase enable adenine-to-guanine (A-to-G) single-nucleotide substitutions in a guide RNA (gRNA)-dependent manner. Here we demonstrate application of this technology in mouse embryos and adult mice. We also show that long gRNAs enable adenine editing at positions one or two bases upstream of the window that is accessible with standard...
Paper Details
Title
Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
Published Date
Apr 27, 2018
Journal
Volume
36
Issue
6
Pages
536 - 539
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History