Molecular simulations for amorphous drug formulation: Polymeric matrix properties relevant to hot-melt extrusion

In the present study molecular modelling was used to evaluate polymeric drug carrier matrix properties suitable for hot-melt extrusion (HME). Specifically, the effect of three commonly used plasticizers, namely, citric acid (CA), triethyl citrate (TEC) and polyethylene glycol (PEG), on Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer, SOL) properties were evaluated with the aid of classical molecular...