Mechanistic insights into ER-associated protein degradation
Abstract
Misfolded proteins of the endoplasmic reticulum (ER) are discarded by a conserved process, called ER-associated protein degradation (ERAD). ERAD substrates are retro-translocated into the cytosol, polyubiquitinated, extracted from the ER membrane, and ultimately degraded by the proteasome. Recent in vitro experiments with purified components have given insight into the mechanism of ERAD. ERAD substrates with misfolded luminal or intramembrane...
Paper Details
Title
Mechanistic insights into ER-associated protein degradation
Published Date
Aug 1, 2018
Volume
53
Pages
22 - 28
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