Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Abstract
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient receptor potential (TRPC) channels. They are activated by diacylglycerol, a lipid second messenger. TRPC6 and TRPC3 are involved in many physiological processes and implicated in human genetic diseases. Here we present the structure of human TRPC6 homotetramer in complex with a newly identified high-affinity inhibitor BTDM solved...
Paper Details
Title
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Published Date
Apr 26, 2018
Journal
Volume
28
Issue
7
Pages
746 - 755
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