A fibrin biofilm covers blood clots and protects from microbial invasion

Volume: 128, Issue: 8, Pages: 3356 - 3368
Published: Aug 1, 2018
Abstract
Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of the external clot face is unknown. Here we show that fibrin transitioned to the blood-air interface through Langmuir film formation, producing a protective film confining clots in human and mouse models. We...
Paper Details
Title
A fibrin biofilm covers blood clots and protects from microbial invasion
Published Date
Aug 1, 2018
Volume
128
Issue
8
Pages
3356 - 3368
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