The BUB3-BUB1 Complex Promotes Telomere DNA Replication
Abstract
Telomeres and telomere-binding proteins form complex secondary nucleoprotein structures that are critical for genome integrity but can present serious challenges during telomere DNA replication. It remains unclear how telomere replication stress is resolved during S phase. Here, we show that the BUB3-BUB1 complex, a component in spindle assembly checkpoint, binds to telomeres during S phase and promotes telomere DNA replication. Loss of the...
Paper Details
Title
The BUB3-BUB1 Complex Promotes Telomere DNA Replication
Published Date
May 1, 2018
Journal
Volume
70
Issue
3
Pages
395 - 407.e4
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