Theanine supplementation prevents liver injury and heat shock response by normalizing hypothalamic-pituitaryadrenal axis hyperactivity in mice subjected to whole body heat stress

Thermal stress evokes heat shock response and activates hypothalamic-pituitaryadrenal (HPA) axis. Additionally, liver injury is an important adverse effect of thermal stress. Considering the anti-stress effects of theanine, an amino acid found in tea plants, we hypothesized that theanine may protect against heat stress. Mice were administered intragastrically with theanine prior to whole body thermal exposure. Theanine prevented the heat-induced...