Bilateral neuroimmune changes in a unilateral murine model of osteoarthritis
Abstract
Purpose: Surgical destabilization of the medial meniscus (DMM) in the mouse knee results in slowly progressive osteoarthritis (OA) in the operated knee and is associated with behaviors indicative of pain. Mice develop mechanical allodynia in the ipsilateral but not the contralateral hind paw by week 4 after DMM surgery and this allodynia is maintained through week 16. In addition, hyperalgesia develops in the ipsilateral but not the...
Paper Details
Title
Bilateral neuroimmune changes in a unilateral murine model of osteoarthritis
Published Date
Apr 1, 2018
Journal
Volume
26
Pages
S359 - S359
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