Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits
Abstract
We propose a novel approach to analyze genomic data that incorporates haplotype information for detecting rare variants within a regional heritability mapping framework. The performance of our approach was tested in a simulation study based on human genotypes. The phenotypes were simulated by generating regional variance using either SNP(s) or haplotype(s). Regional genomic relationship matrices, constructed with either a SNP-based or a...
Paper Details
Title
Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits
Published Date
Mar 21, 2018
Journal
Volume
8
Issue
1
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