Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target
Abstract
Significant metabolic changes occur in inflammation to respond to the new energetic needs of cells. Mitochondria are addressed not only to produce ATP, but also to supply substrates, such citrate, to produce pro-inflammatory molecules. In this context, most of the citrate is diverted from Krebs cycle and channeled into the “citrate pathway” leading to the increase in the export of citrate into cytosol by the Mitochondrial Citrate Carrier (CIC)...
Paper Details
Title
Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target
Published Date
Jan 3, 2020
Journal
Volume
26
Issue
40
Pages
7104 - 7116
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