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Glucosamine for the Treatment of Osteoarthritis: The Time Has Come for Higher-Dose Trials

Published on Mar 4, 2019in Journal of Dietary Supplements
· DOI :10.1080/19390211.2018.1448920
Mark F. McCarty25
Estimated H-index: 25
,
James H. O'Keefe52
Estimated H-index: 52
(UMKC: University of Missouri–Kansas City),
James J. DiNicolantonio24
Estimated H-index: 24
Cite
Abstract
ABSTRACTAlthough clinical trials with glucosamine in osteoarthritis have yielded mixed results, leading to doubts about its efficacy, the utility of glucosamine for preventing joint destruction and inflammation is well documented in rodent models of arthritis, including models of spontaneous osteoarthritis. The benefit of oral glucosamine in adjuvant arthritis is markedly dose dependent, likely reflecting a modulation of tissue levels of UDP-N-acetylglucosamine that in turn influences mucopolysaccharide synthesis and the extent of protein O-GlcNAcylation. Importantly, the minimal oral dose of glucosamine that exerts a detectible benefit in adjuvant arthritis achieves plasma glucosamine levels similar to those achieved when the standard clinical dose of glucosamine, 1.5 g daily, is administered as a bolus. The response of plasma glucosamine levels to an increase in glucosamine intake is nearly linear. Remarkably, every published clinical trial with glucosamine has employed the same 1.5 g dose that Rottapha...
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References89
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Published on Aug 1, 2017in Radiology7.61
Alexandra S. Gersing9
Estimated H-index: 9
,
Benedikt J. Schwaiger11
Estimated H-index: 11
+ 7 AuthorsThomas M. Link76
Estimated H-index: 76
Weight loss of more than 5% is associated with a reduced progression of knee cartilage and meniscal degeneration at MR imaging in obese and overweight individuals with risk factors for osteoarthritis or mild to moderate radiographic evidence for osteoarthritis.
Published on Jan 8, 2016in Circulation Research15.86
Paul M. Ridker192
Estimated H-index: 192
(Brigham and Women's Hospital)
Plasma levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) predict vascular risk with an effect estimate as large as that of total or high-density lipoprotein cholesterol. Further, randomized trial data addressing hsCRP have been central to understanding the anti-inflammatory effects of statin therapy and have consistently demonstrated on-treatment hsCRP levels to be as powerful a predictor of residual cardiovascular risk as on-treatment levels of low-density lipopro...
Published on Jun 1, 2015in The Spine Journal3.20
Gwendolyn A. Sowa24
Estimated H-index: 24
(University of Pittsburgh),
J. Paulo Coelho3
Estimated H-index: 3
(University of Pittsburgh)
+ 6 AuthorsJame D. Kang1
Estimated H-index: 1
(University of Pittsburgh)
Background context Glucosamine has gained widespread use among patients, despite inconclusive efficacy data. Inconsistency in the clinical literature may be related to lack of understanding of the effects of glucosamine on the intervertebral disc, and therefore, improper patient selection.
Published on Feb 26, 2015in PLOS ONE2.78
Sandi L. Navarro12
Estimated H-index: 12
(Fred Hutchinson Cancer Research Center),
Emily White51
Estimated H-index: 51
(Fred Hutchinson Cancer Research Center)
+ 6 AuthorsJohanna W. Lampe51
Estimated H-index: 51
(Fred Hutchinson Cancer Research Center)
Background Glucosamine and chondroitin are popular non-vitamin dietary supplements used for osteoarthritis. Long-term use is associated with lower incidence of colorectal and lung cancers and with lower mortality; however, the mechanism underlying these observations is unknown. In vitro and animal studies show that glucosamine and chondroitin inhibit NF-kB, a central mediator of inflammation, but no definitive trials have been done in healthy humans.
Published on Jun 1, 2014in Journal of Alternative and Complementary Medicine1.87
Elizabeth D. Kantor15
Estimated H-index: 15
(Harvard University),
Johanna W. Lampe51
Estimated H-index: 51
(UW: University of Washington)
+ 3 AuthorsEmily White63
Estimated H-index: 63
(UW: University of Washington)
Abstract Objectives: Glucosamine and chondroitin supplements have been shown to have anti-inflammatory properties in both in vitro studies and animal models; however, little is known about these relationships in humans. The VITamins and Lifestyle (VITAL) biomarker study evaluated the associations between use of these supplements and a panel of circulating inflammatory biomarkers. Design: Study participants included 217 men and women age 50–75 years living in the Seattle metropolitan area. Use of...
Published on May 1, 2014in Journal of Gastroenterology and Hepatology3.63
Youn Kyung Bak2
Estimated H-index: 2
(Sookmyung Women's University),
Johanna W. Lampe51
Estimated H-index: 51
(Fred Hutchinson Cancer Research Center),
Mi-Kyung Sung34
Estimated H-index: 34
(Sookmyung Women's University)
Background and Aim Epidemiological evidences suggested an inverse association between the use of glucosamine supplements and colorectal cancer (CRC) risk. In this study, the efficacy of glucosamine to attenuate dextran sodium sulfate (DSS)-induced colitis, a precancerous condition for CRC, was evaluated. Methods C57BL/6 mice were separated into three groups receiving glucosamine sulfate at concentrations of 0, 0.05, and 0.10% (w/w) of AIN-93G diet, respectively for 4 weeks. Colitis was induced b...
Published on May 1, 2014in Nature Communications11.88
Sandra Weimer5
Estimated H-index: 5
,
Josephine Priebs1
Estimated H-index: 1
+ 13 AuthorsAndreas F.H. Pfeiffer67
Estimated H-index: 67
D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that activates AMP-activated protein kinase (AMPK/AAK-2) and increases mitochondrial biogenesis. Consistent with the concept of mitohormesis, GlcN promotes increased formation of mitochon...
Published on Apr 1, 2014in Free Radical Biology and Medicine5.66
Yuh-Lin Wu14
Estimated H-index: 14
(NYMU: National Yang-Ming University),
An-Hsuan Lin7
Estimated H-index: 7
(NYMU: National Yang-Ming University)
+ 5 AuthorsYu Ru Kou29
Estimated H-index: 29
(NYMU: National Yang-Ming University)
Abstract Cigarette smoking causes persistent lung inflammation that is mainly regulated by redox-sensitive pathways. We have reported that cigarette smoke (CS) activates a NADPH oxidase-dependent reactive oxygen species (ROS)-sensitive AMP-activated protein kinase (AMPK) signaling pathway leading to induction of lung inflammation. Glucosamine, a dietary supplement used to treat osteoarthritis, has antioxidant and anti-inflammatory properties. However, whether glucosamine has similar beneficial e...
Published on Feb 1, 2014in Journal of Pharmaceutical Sciences3.20
Ali Aghazadeh-Habashi10
Estimated H-index: 10
(University of Alberta Faculty of Pharmacy and Pharmaceutical Sciences),
M.H. Gilzad Kohan1
Estimated H-index: 1
(University of Alberta Faculty of Pharmacy and Pharmaceutical Sciences)
+ 1 AuthorsFakhreddin Jamali38
Estimated H-index: 38
(University of Alberta Faculty of Pharmacy and Pharmaceutical Sciences)
ABSTRACT There is a debate on the dose dependency, concentration-effect, hence, the beneficial effect of glucosamine (GlcN), a widely used anti-inflammatory natural product. We investigated dose/concentration-effect relationship and determined its minimum effective dose/concentration in rats with adjuvant arthritis (AA, Mycobacterium butyricum in squalene) both as preventive and ameliorating interventions. To control already emerged arthritis, rats received oral doses of placebo or 160 mg/kg.day...
Published on Aug 1, 2013in Expert Review of Proteomics2.96
Junfeng Ma5
Estimated H-index: 5
(JHUSOM: Johns Hopkins University School of Medicine),
Gerald W. Hart98
Estimated H-index: 98
(JHUSOM: Johns Hopkins University School of Medicine)
The post-translational modification of serine and threonine residues of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O-GlcNAcylation serves as a key regulator of critical biological processes including transcription, translation, proteasomal degradation, signal transduction and apoptosis. Increased O-GlcNAcylation is directly linked to insulin resistance and to hyperglycemia-induced glucose toxicity, two hallmarks of diabetes and diab...
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