Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Volume: 128, Issue: 5, Pages: 2127 - 2143
Published: May 1, 2018
Abstract
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and...
Paper Details
Title
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
Published Date
May 1, 2018
Volume
128
Issue
5
Pages
2127 - 2143
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