Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma
Abstract
Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual patient's metastatic risk, and provide the basis to determine an individualized targeted therapeutic...
Paper Details
Title
Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma
Published Date
Jun 26, 2018
Volume
57
Issue
8
Pages
387 - 400
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