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Assessment of hair cortisol as a potential biomarker for possible adrenal suppression due to inhaled corticosteroid use in children with asthma: A retrospective observational study

Published on Jun 1, 2018in Clinical Biochemistry 2.43
· DOI :10.1016/j.clinbiochem.2018.04.006
Laura Smy2
Estimated H-index: 2
(U of T: University of Toronto),
Kaitlyn Shaw5
Estimated H-index: 5
(UBC: University of British Columbia)
+ 5 AuthorsGideon Koren83
Estimated H-index: 83
(U of T: University of Toronto)
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Abstract
Abstract Background Inhaled corticosteroids (ICS) are the recommended long-term control therapy for asthma in children. However, concern exists regarding potential adrenal suppression with chronic ICS use. Our pilot study reported that hair cortisol in children was 50% lower during ICS therapy than prior to therapy, suggestive of adrenal suppression. Objective To evaluate hair cortisol concentration (HCC) as a potential biomarker for possible adrenal suppression from ICS use in children with asthma. Methods A retrospective observational study was performed at asthma clinics in Vancouver, Winnipeg, and Toronto, Canada. Children ( n  = 586) were recruited from July 2012 to December 2014 inclusive of those without asthma, with asthma not using ICS, and with asthma using ICS. The most recent three-month HCC was measured by enzyme immunoassay and compared among the groups. Quantile regression analysis was performed to identify factors potentially affecting HCC. Results The median HCC was not significantly different among the children: No ICS ( n  = 47, 6.7 ng/g, interquartile range (IQR) 3.7–9.8 ng/g), ICS Treated ( n  = 360, 6.5 ng/g, IQR 3.8–14.3 ng/g), and Controls ( n  = 53, 5.8 ng/g, IQR 4.6–16.7 ng/g). 5.6% of the children using ICS had hair cortisol P Conclusions Results suggest HCC may be a potential biomarker for adrenal suppression as a population of children using ICS with HCC
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References45
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Published on Jan 1, 2018in Psychoneuroendocrinology 4.01
N.A. Gray1
Estimated H-index: 1
(UCT: University of Cape Town),
A. Dhana1
Estimated H-index: 1
(UCT: University of Cape Town)
+ 3 AuthorsDan J. Stein104
Estimated H-index: 104
(UCT: University of Cape Town)
Abstract Background Several factors are known contribute to hair cortisol concentration (HCC) in adults. However, there is less research on determinants of HCC in children and adolescents. HCC is a valuable tool for medical research pertaining to the hypothalamic-pituitary-adrenal (HPA) axis. This review aims to assess the extent to which established determinants of HCC in adults have been consistently reported in children (birth – 18 years) and to identify determinants of HCC specific to this a...
Published on Jan 1, 2017in Hormone Research in Paediatrics 2.32
Maaike P. Smit1
Estimated H-index: 1
,
Ed Van Leer1
Estimated H-index: 1
+ 3 AuthorsErica L.T. van den Akker18
Estimated H-index: 18
Introduction: Inhaled corticosteroids (ICS) can interfere with the hypothalamic-pituitary-adrenal (HPA) axis and may lead to adrenal insufficiency, resulting in a
Published on Dec 1, 2016in BMC Pregnancy and Childbirth 2.41
Laura Smy2
Estimated H-index: 2
(U of T: University of Toronto),
Kaitlyn Shaw5
Estimated H-index: 5
(UBC: University of British Columbia)
+ 4 AuthorsGideon Koren83
Estimated H-index: 83
(U of T: University of Toronto)
Background Cortisol is a hormone involved in many physiological functions including fetal maturation and epigenetic programming during pregnancy. This study aimed to use hair cortisol as a biomarker of chronic inhaled corticosteroid (ICS) exposure and assess the potential effects of asthma on the hypothalamic-pituitary-adrenal (HPA) axis in pregnant women. We hypothesized that pregnant women with asthma treated with ICS would exhibit lower hair cortisol concentrations, indicative of adrenal supp...
Published on Sep 1, 2016in Psychoneuroendocrinology 4.01
Sarah J. Short12
Estimated H-index: 12
(UNC: University of North Carolina at Chapel Hill),
Tobias Stalder34
Estimated H-index: 34
(TUD: Dresden University of Technology)
+ 5 AuthorsClaudia Buss37
Estimated H-index: 37
(Charité)
Abstract Characterization of cortisol production, regulation and function is of considerable interest and relevance given its ubiquitous role in virtually all aspects of physiology, health and disease risk. The quantification of cortisol concentration in hair has been proposed as a promising approach for the retrospective assessment of integrated, long-term cortisol production. However, human research is still needed to directly test and validate current assumptions about which aspects of cortis...
Published on Sep 1, 2016in Psychoneuroendocrinology 4.01
Tobias Stalder34
Estimated H-index: 34
(TUD: Dresden University of Technology),
Susann Steudte-Schmiedgen10
Estimated H-index: 10
(TUD: Dresden University of Technology)
+ 5 AuthorsRobert Miller18
Estimated H-index: 18
(TUD: Dresden University of Technology)
Abstract The analysis of hair cortisol concentrations (HCC) is a relatively new strategy to measure long-term cumulative cortisol levels, which is increasingly used in psychoneuroendocrinological research. Here, we conduct a first comprehensive meta-analysis of HCC research based on aggregated data from a total of 124 (sub)samples (66 independent studies; total N = 10,289). We seek to answer two central questions: (i) Which covariates and basic features of HCC need to be considered in future res...
Published on Nov 1, 2015in European Journal of Pediatrics 2.19
Ozlem Cavkaytar9
Estimated H-index: 9
(Hacettepe University),
Dogus Vuralli4
Estimated H-index: 4
(Hacettepe University)
+ 5 AuthorsBulent Enis Sekerel21
Estimated H-index: 21
(Hacettepe University)
The possible risk of adverse effects due to regular use of inhaled corticosteroids (ICS) is a real concern. Our aim was to describe the factors that have an impact on hypothalamic-pituitary-adrenal axis suppression (HPA-AS) in children and adolescents taking ICS regularly. The HPA axis status of patients who were on moderate-to-high-dose ICS [>176 and >264 μg/day fluticasone propionate-hydrofluoroalkane (FP-HFA) for patients 0–11 and ≥12 years, respectively] was investigated. Various types of IC...
Published on Aug 1, 2015in Clinical Endocrinology 2.90
Gerard Noppe7
Estimated H-index: 7
(EUR: Erasmus University Rotterdam),
Yolanda B. de Rijke30
Estimated H-index: 30
(EUR: Erasmus University Rotterdam)
+ 2 AuthorsElisabeth F.C. van Rossum40
Estimated H-index: 40
(EUR: Erasmus University Rotterdam)
SummaryBackground Liquid chromatography–tandem mass spectrometry (LC-MS/MS) is the method of choice for quantification of steroids. Human scalp hair provides the possibility to measure long-term retrospective steroid concentrations, which is especially useful for steroids with large time-dependent fluctuations in concentration, such as the glucocorticoid cortisol. Aim We set up and validated a LC-MS/MS-based method for long-term steroid profiling, quantifying cortisol, cortisone, testosterone, a...
Published on Feb 1, 2015in Annals of Epidemiology 2.55
Adaeze C. Wosu7
Estimated H-index: 7
(Harvard University),
Bizu Gelaye24
Estimated H-index: 24
(Harvard University)
+ 4 AuthorsMichelle A. Williams66
Estimated H-index: 66
(Harvard University)
Abstract Purpose We investigated the feasibility of obtaining hair samples from men and women at community-based barbershops and hair salons for analysis of cortisol and assessed sociodemographic and lifestyle correlates of hair cortisol concentrations (HCCs). A total of 102 participants completed the study. Methods Research staff interviewed participants using a structured questionnaire, and samples of hair were collected. HCCs were determined using liquid chromatography-tandem mass spectrometr...
Published on Feb 1, 2015in Therapeutic Drug Monitoring 2.05
Evan Russell10
Estimated H-index: 10
,
Clemens Kirschbaum101
Estimated H-index: 101
+ 5 AuthorsGideon Koren80
Estimated H-index: 80
Background: The importance of hair cortisol as a long-term retrospective measure of systemic cortisol exposure is being increasingly recognized, and over recent years, the field of hair cortisol analysis has seen rapid expansion with laboratories around the globe, integrating hair cortisol analysis into their study designs. These laboratories use different methods of analysis, and presently, no attempt has been made to compare them. To move toward clinical utilization of this novel method, inter...
Published on Sep 1, 2014in Acta Paediatrica 2.27
Arvid Wa Kamps4
Estimated H-index: 4
,
Marco Molenmaker1
Estimated H-index: 1
+ 3 AuthorsNic J. G. M. Veeger42
Estimated H-index: 42
Aim: Noninvasive measurement of long-term cortisol levels is a useful way of evaluating the effect of chronic disease on the hypothalamic-pituitary-adrenal axis in children. The aim of this pilot study was to compare hair cortisol levels in children using inhaled corticosteroids for asthma and healthy children and to determine the association with short-term salivary cortisol levels. Methods: Cortisol levels were measured in the scalp hair and saliva of prepubertal children with asthma (n = 10) ...
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